Structural Determinants of a Glucocorticoid Receptor Recognition Element
نویسندگان
چکیده
منابع مشابه
Determinants for DNA-binding site recognition by the glucocorticoid receptor.
The glucocorticoid receptor binds with high specificity to glucocorticoid response elements, discriminating them from other closely related binding sites. Three amino acids in the recognition alpha-helix of the DNA-binding domain of the receptor are primarily responsible for this specific DNA binding activity. In this study we analyze in detail how these residues determine the specific DNA bind...
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DNA glycosylases catalyze the scission of the N-glycosyl bond linking either a damaged or mismatched base to the DNA sugar phosphate backbone. T4 endonuclease V is a glycosylase/apurinic (AP) lyase that is specific for UV light-induced cis-syn pyrimidine dimers. As a proposed transition state analog/inhibitor for glycosylases, a phosphoramidite derivative containing a pyrrolidine residue has be...
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ژورنال
عنوان ژورنال: Molecular Endocrinology
سال: 1990
ISSN: 0888-8809,1944-9917
DOI: 10.1210/mend-4-12-1866